The serotonin releaser fenfluramine alters the auditory responses of inferior colliculus neurons

  title={The serotonin releaser fenfluramine alters the auditory responses of inferior colliculus neurons},
  author={Ian C. Hall and Laura M. Hurley},
  journal={Hearing Research},

Figures and Tables from this paper

Serotonin 1B receptor modulates frequency response curves and spectral integration in the inferior colliculus by reducing GABAergic inhibition.

In vivo extracellular recording and iontophoresis of the selective 5-HT1B agonist CP93129 were used to characterize inhibition within and surrounding frequency response curves using two-tone protocols to indirectly measure inhibition as a decrease in spikes relative to an excitatory tone alone, consistent with the reduction of GABAA-mediated inhibition by 5- HT1B receptors in the IC.

Social regulation of serotonin in the auditory midbrain.

Findings show that during social interaction, serotonin in the IC is influenced by extrinsic factors such as the directness of social interaction and intrinsic factors including age, individual identity, and experience.

From behavioral context to receptors: serotonergic modulatory pathways in the IC

A broad model of serotonin receptors as a link between behavioral context and reconfiguration of circuitry in the IC is supported, and the resulting possibility that plasticity at the level of specific receptor types could alter the relationship between context and circuit function is considered.

Modulation of auditory brainstem responses by serotonin and specific serotonin receptors

Serotonin, estrus, and social context influence c-Fos immunoreactivity in the inferior colliculus.

The findings show that the effects of serotonin on c-Fos activity in the IC of females is dependent on both external context and reproductive state, and suggest that these effects occur downstream of serotonin release.

Chronic low‐level lead exposure affects the monoaminergic system in the mouse superior olivary complex

Evidence is provided that Pb exposure during development alters normal monoaminergic expression in the auditory brainstem, which is an important component in sound detection in noisy environments and in selective auditory attention.



Serotonin effects on frequency tuning of inferior colliculus neurons.

The results suggest that serotonin, whose release varies with behavioral state, functionally reconfigures the circuitry of the IC and may modulate the perception of acoustic signals under different behavioral states.

Serotonin Shifts First-Spike Latencies of Inferior Colliculus Neurons

The results support the general conclusion that changes in latency are an important part of the neuromodulatory repertoire of serotonin within the auditory system and show that serotonin can change latency either in conjunction with broad changes in other aspects of neuronal excitability or in highly specific ways.

Serotonin modulates responses to species-specific vocalizations in the inferior colliculus

The effects of iontophoretically applied serotonin on the responses of individual inferior colliculus neurons to a variety of recorded species-specific vocalizations were examined and it was found that a functional consequence of these serotonin-evoked changes would be to change the population response to species- specific vocalizations.

Serotonin Differentially Modulates Responses to Tones and Frequency-Modulated Sweeps in the Inferior Colliculus

The results suggest that the population activity evoked by a particular sound is not simply a consequence of the hard wiring that connects the IC to lower and higher regions but rather is highly dynamic because of the functional reconfigurations induced by serotonin and almost certainly other neuromodulators as well.

Serotonin modulates auditory information processing in the cochlear nucleus of the rat