The serotonin releaser fenfluramine alters the auditory responses of inferior colliculus neurons

@article{Hall2007TheSR,
  title={The serotonin releaser fenfluramine alters the auditory responses of inferior colliculus neurons},
  author={Ian C. Hall and Laura M. Hurley},
  journal={Hearing Research},
  year={2007},
  volume={228},
  pages={82-94}
}

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References

SHOWING 1-10 OF 82 REFERENCES

Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.

  • L. Hurley
  • Biology, Psychology
    Journal of neurophysiology
  • 2006
TLDR
Evidence suggests that the diversity of serotonin receptor sub types in the IC is likely to account for at least some of the variability of the effects of serotonin and that receptor subtypes fulfill specialized roles in auditory processing.

Serotonin effects on frequency tuning of inferior colliculus neurons.

TLDR
The results suggest that serotonin, whose release varies with behavioral state, functionally reconfigures the circuitry of the IC and may modulate the perception of acoustic signals under different behavioral states.

Serotonin Shifts First-Spike Latencies of Inferior Colliculus Neurons

TLDR
The results support the general conclusion that changes in latency are an important part of the neuromodulatory repertoire of serotonin within the auditory system and show that serotonin can change latency either in conjunction with broad changes in other aspects of neuronal excitability or in highly specific ways.

Serotonin modulates responses to species-specific vocalizations in the inferior colliculus

TLDR
The effects of iontophoretically applied serotonin on the responses of individual inferior colliculus neurons to a variety of recorded species-specific vocalizations were examined and it was found that a functional consequence of these serotonin-evoked changes would be to change the population response to species- specific vocalizations.

Serotonin Differentially Modulates Responses to Tones and Frequency-Modulated Sweeps in the Inferior Colliculus

TLDR
The results suggest that the population activity evoked by a particular sound is not simply a consequence of the hard wiring that connects the IC to lower and higher regions but rather is highly dynamic because of the functional reconfigurations induced by serotonin and almost certainly other neuromodulators as well.
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