The serotonin 5-HT2A receptor agonist TCB-2: a behavioral and neurophysiological analysis

@article{Fox2009TheS5,
  title={The serotonin 5-HT2A receptor agonist TCB-2: a behavioral and neurophysiological analysis},
  author={Meredith A. Fox and Helen T. French and Justin L. LaPorte and Adele R. Blackler and Dennis L. Murphy},
  journal={Psychopharmacology},
  year={2009},
  volume={212},
  pages={13-23}
}
RationaleThere are few reports on the high-affinity 5-HT2A agonist (4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide (TCB-2).ObjectivesHere we provide the first behavioral and neurophysiological profile of TCB-2 in C57BL/6J mice, with direct comparisons to the 5-HT2A/2C agonist (±)-2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI), in addition to determinations of 5-HT2A mediation via pretreatment with the selective 5-HT2A antagonist MDL 11,939.ResultsIn a dose-dependent manner… 

Pharmacological and behavioral characterization of the 5-HT2A receptor in C57BL/6N mice

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It is shown for the first time that the chronic activation of the 5-HT2A receptor with agonists has affected the BDNF system almost on all levels-transcription, proBDNF production, TrkB and p75NTR receptors' level.

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Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine

These data indicate that 5-HT2C receptors within the mPFC and the NAC modulate the reinforcing effects of cocaine and provide evidence that5- HT2C receptor agonists could be a possible drug discovery target for the treatment of psychostimulant addiction.

Role of 5-HT(1A)- and 5-HT(2A) receptors for the murine model of the serotonin syndrome.

Role for serotonin 2 A ( 5-HT 2 A ) and 2 C ( 5-HT 2 C ) receptors in experimental absence seizures

5-HT1ARs and 5-HT2CRs negatively control the expression of experimental ASs, indicating that selective agonists at these 5- HT2R subtypes might be potential novel anti-absence drugs.

5-HT2A and mGlu2/3 receptor interactions: on their relevance to cognitive function and psychosis

In-vitro and in-vivo studies documenting the important relationship between 5-HT2A and mGlu2/3 receptors, with relevance to both normal behavioral function and psychosis are focused on.
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