The serotonin 5‐HT1D receptor gene and attention‐deficit hyperactivity disorder in Chinese Han subjects

@article{Li2006TheS5,
  title={The serotonin 5‐HT1D receptor gene and attention‐deficit hyperactivity disorder in Chinese Han subjects},
  author={Jun Li and Xia Zhang and Yufeng Wang and Ru-lun Zhou and Hao-bo Zhang and Li Yang and Bing Wang and Stephen V. Faraone},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2006},
  volume={141B}
}
  • Jun Li, Xia Zhang, S. Faraone
  • Published 2006
  • Biology
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Attention‐deficit/hyperactivity disorder (ADHD) is a heritable disease. Serotonin is one of the neurotransmitters involved in the etiology of ADHD. Serotonin‐1D receptors are autoreceptors which can regulate the release of serotonin in brain, so the HTR1D gene may be predisposing. The current study genotyped two variants of HTR1D gene in 272 ADHD trios of Chinese ethnicity, that is 1350T > C in the coding region and 1236A > G in 3′‐UTR by the use of transmission disequilibrium test (TDT). The A… 
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Linkage analysis of attention deficit hyperactivity disorder
  • S. Faraone, A. Doyle, J. Biederman
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
The absence of regions of significant or suggestive linkage in these data suggest that there are no genes of large effect contributing to the ADHD phenotype.
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References

SHOWING 1-10 OF 28 REFERENCES
Serotonin 5‐HT1B receptor gene and attention deficit hyperactivity disorder in Chinese Han subjects
  • Jun Li, Yufeng Wang, S. Faraone
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
TLDR
Investigation of the A‐161T and G861C polymorphisms in the 5‐HT1B receptor gene in ADHD trios from the Chinese Han population found no association with ADHD but did find a tendency for excess transmission of the 861G allele to offspring with inattentive ADHD.
The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder
TLDR
Results from this study provide additional evidence that serotonin genes may be important risk factors for the development of ADHD and suggest the involvement of the 5-HT1B receptors in locomotor behaviour.
Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population
  • Jun Li, Yufeng Wang, S. Faraone
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2006
Attention deficit hyperactivity disorder (ADHD) is a severe behavioral disorder in children known to have a substantial genetic component. Prior studies have implicated serotonin genes in the
Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT1B receptor gene in 273 nuclear families from a multi-centre sample
TLDR
Preliminary data suggest an important role for the serotonin system in the development of ADHD, and suggests that some of the genetic predisposition to ADHD might be due to DNA variation at serotonin system genes.
Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder
TLDR
The results link potentially functional TPH2 variations to the pathophysiology of ADHD, and further support the relevance of 5-HT in disorders related to altered motor activity and cognitive processes.
Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis
TLDR
This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD.
Lack of association between the tryptophan hydroxylase gene A218C polymorphism and attention-deficit hyperactivity disorder in Chinese Han population.
TLDR
The data indicate that the TPH gene A218C polymorphism may not be a susceptibility factor of ADHD in the Chinese Han population.
Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder.
TLDR
A significant decrease in the short/short 5-HTTLPR genotype was observed in the ADHD type III combined group compared with the HRR-derived control group, and these first findings should be interpreted cautiously until replicated in independently recruited clinical samples.
Significance of Serotonin Transporter Gene 5-HTTLPR and Variable Number of Tandem Repeat Polymorphism in Attention Deficit Hyperactivity Disorder
TLDR
The lack of an S/S variant of 5-HTTLPR polymorphism of the STin2.12/12 variant of VNTR polymorphism appears to be associated with an increased risk of ADHD.
Mapping of the serotonin 5-HT1D alpha autoreceptor gene (HTR1D) on chromosome 1 using a silent polymorphism in the coding region.
TLDR
This analysis demonstrates that functionally significant coding sequence variants of the 5-HT{sub 1D{alpha}} are probably not abundant either among alcoholics or in the general population, and should also be useful for linkage studies in populations and in families.
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1
2
3
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