The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen

@article{Canal2010TheS2,
  title={The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen},
  author={Clinton E Canal and Uade B. Olaghere da Silva and Paul J Gresch and Erin E. Watt and Elaine Sanders-Bush and David C. Airey},
  journal={Psychopharmacology},
  year={2010},
  volume={209},
  pages={163-174}
}
Hallucinogenic serotonin 2A (5-HT2A) receptor partial agonists, such as (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), induce a frontal cortex-dependent head-twitch response (HTR) in rodents, a behavioral proxy of a hallucinogenic response that is blocked by 5-HT2A receptor antagonists. In addition to 5-HT2A receptors, DOI and most other serotonin-like hallucinogens have high affinity and potency as partial agonists at 5-HT2C receptors. We tested for involvement of 5… CONTINUE READING