The serotonergic system in the neurobiology of depression: Relevance for novel antidepressants

  title={The serotonergic system in the neurobiology of depression: Relevance for novel antidepressants},
  author={S. K{\"o}hler and Katharina Cierpinsky and G. Kronenberg and M. Adli},
  journal={Journal of Psychopharmacology},
  pages={13 - 22}
  • S. Köhler, Katharina Cierpinsky, +1 author M. Adli
  • Published 2016
  • Medicine, Psychology
  • Journal of Psychopharmacology
  • The monoamine hypothesis of depression posits that an imbalance in monoaminergic neurotransmission is causally related to the clinical features of depression. Antidepressants influencing serotonin mainly aim at raising serotonin concentrations, thereby increasing serotonergic transmission at the level of the synapse, for example by inhibiting the serotonin transporter. However, the serotonin system is multifaceted. Different serotonin receptor subtypes turn the serotonergic system into a… CONTINUE READING
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    Publications referenced by this paper.
    The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).
    • 6,787
    • PDF
    Relationship of neurotransmitters to the symptoms of major depressive disorder.
    • 282
    The 5-HT7 receptor and disorders of the nervous system: an overview
    • 201
    Altered Serotonin 1A Binding in Major Depression: A [carbonyl-C-11]WAY100635 Positron Emission Tomography Study
    • 342