The serotonergic system in the neurobiology of depression: Relevance for novel antidepressants

@article{Khler2016TheSS,
  title={The serotonergic system in the neurobiology of depression: Relevance for novel antidepressants},
  author={S. K{\"o}hler and Katharina Cierpinsky and G. Kronenberg and M. Adli},
  journal={Journal of Psychopharmacology},
  year={2016},
  volume={30},
  pages={13 - 22}
}
The monoamine hypothesis of depression posits that an imbalance in monoaminergic neurotransmission is causally related to the clinical features of depression. Antidepressants influencing serotonin mainly aim at raising serotonin concentrations, thereby increasing serotonergic transmission at the level of the synapse, for example by inhibiting the serotonin transporter. However, the serotonin system is multifaceted. Different serotonin receptor subtypes turn the serotonergic system into a… Expand
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