The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study.

@article{Leone2000TheSA,
  title={The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study.},
  author={Massimo Leone and Angelo Attanasio and Danilo Croci and Graziella Filippini and Domenico D'amico and Licia Grazzi and Angelo Nespolo and Gennaro Bussone},
  journal={Neurology},
  year={2000},
  volume={55 1},
  pages={136-9}
}
In a double-blind study versus placebo, the serotonergic agent m-chlorophenylpiperazine (mCPP) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mCPP (0.5 mg/kg) to induce typical migraine attacks. In the following 24 hours there were more migraines after mCPP than after placebo in both groups. These findings are consistent with involvement of 5HT2B,2C,1A receptor subtypes in the pathophysiology of migraine. 

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