A Rare Case Presentation: Diagnosing Primary Biliary Cholangitis in a Male Patient With Concomitant Type 1 Diabetes
This case report presents the rare case of a male patient with type 1 diabetes recently diagnosed with PBC, and suggests no significant histological, serological, or biochemical differences between PBC in males and females.
The Discovery of the Hepatitis D Virus: Three Princes of Serendip and the Recognition of Autoantibodies to Liver‐Kidney Microsomes
- MedicineClinical liver disease
The allure of CH was that it seemed to be the missing link between cirrhosis and acute hepatitis, and cardiologists now find that serum alkaline phosphatase and gamma-glutamyl transferase are useful in assessing coronary artery disease.
Primary biliary cholangitis: Diagnosis and treatment
- MedicineLiver Research
The epidemiology, natural history, predictive and diagnostic features, and current and emerging treatments for Primary biliary cholangitis are reviewed to provide a better understanding of PBC in this patient population.
Diagnosis of primary biliary cirrhosis.
- MedicineBest practice & research. Clinical gastroenterology
Liver biopsy remains useful in certain settings where clarity is needed to confirm diagnosis, exclude alternative disease, and assess the relative contribution of PBC to other co-existent liver injury, and seeks to demonstrate in particular the classic bile duct lesions, as well as the degree of interface activity.
Primary biliary cirrhosis
- MedicineThe Lancet
Evidence supporting the autoimmune nature of primary biliary cirrhosis includes the appearance of highly specific antimitochondrial antibodies (AMAs) and autoreactive T cells and findings of epidemiological studies and murine models suggest a possible role for exogenous chemicals and infectious agents through molecular mimicry.
The autoimmunity of primary biliary cirrhosis and the clonal selection theory
- Biology, MedicineImmunology and cell biology
The unique apoptotic features shown for cholangiocytes are the ideal setting for the development of mitochondrial autoantigen presentation to the immune system through macrophages and AMA; thus, turning the non‐traditional mitochondrial antigen into a traditional one.
CHAPTER 54 – Primary Biliary Cirrhosis
Though genetics should be regarded as the major determinant in susceptibility to PBC, several other factors have been proposed, including a history of previous infections, comorbidity with other autoimmune diseases, and lifestyle factors, such as smoking and a high-fat diet.
The liver has a body—A Cook's tour
- History, MedicineHepatology
The physical examination not only has an illustrious pedigree but is still rewarding in hepatology, as it can indicate the presence of liver disease, assess its severity and, together with the patient’s history, give some intuition as to its cause.
SHOWING 1-10 OF 25 REFERENCES
Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)
- MedicineVirchows Archiv A
Staging of liver biopsy specimens from patients with chronic non-suppurative destructive cholangitis (CNDC) has become an important part of clinical studies that are currently done in many centers, and methods based on uniform criteria that are applicable to all specimens and are easily reproducible are suggested.
Immunopathogenesis of primary biliary cirrhosis.
- Medicine, BiologySeminars in liver disease
Findings help to clarify the pathogenic mechanism of PBC and suggest that induction may be secondary to a primary response to a xenobiotic that is normally metabolized in an estrogen-dependent pathway.
Portrait of a Killer: Jack the Ripper--Case Closed
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Walker JG, Doniach D, Roitt IM, Sherlock S. Serological tests in diagnosis of primary biliary cirrhosis [Lancet 1965;i:827–831]
Serological tests have been used to distinguish between Primary Biliary Cirrhosis and chronic idiopathic obstructive jaundice, which may be extremely difficult to differentiate from obstruction to main bileducts which requires surgical relief.
Antimitochondrial antibodies in primary biliary cirrhosis.
- Biology, MedicineSeminars in liver disease
increasing evidence, including the specific association of AMA with PBC, suggests that AMA is not an epiphenomenon of the disease but plays a significant role in the pathogenesis of PBC.
Autoantibodies against "nuclear dots" in primary biliary cirrhosis.
- Biology, MedicineSeminars in liver disease
Knowledge on the structure and putative function of two nuclear autoantigens, the Sp100 and PML proteins, which are present in so-called nuclear dots (NDs) and against which autoantibodies arepresent in a subpopulation of PBC patients are summarized.
Antimitochondrial antibody-negative primary biliary cirrhosis.
- MedicineThe American journal of gastroenterology
Patients with histological features of primary biliary cirrhosis, whether antimitochondrial antibody positive or negative, are quite comparable with respect to clinical and biochemical features.
Antimitochondrial antibody negative primary biliary cirrhosis: a distinct syndrome of autoimmune cholangitis.
- Biology, MedicineGut
A group of patients with the clinical and histological features of PBC but who do not fulfil the usual criteria necessary to make this diagnosis are described, believing they are distinct from PBC and have a syndrome of autoimmune cholangitis.
PBC 95k, a 95-kilodalton nuclear autoantigen in primary biliary cirrhosis.
- Biology, MedicineArthritis and rheumatism
Affinity-purified antibodies from the 95-kd protein reproduced the nuclear dot immunofluorescence staining pattern, demonstrating that this polypeptide is located in the nuclear dots.