The serology of the Addison‐Gull syndrome

@article{Reuben2003TheSO,
  title={The serology of the Addison‐Gull syndrome},
  author={Adrian Reuben},
  journal={Hepatology},
  year={2003},
  volume={37}
}
  • A. Reuben
  • Published 1 January 2003
  • Medicine
  • Hepatology
A Rare Case Presentation: Diagnosing Primary Biliary Cholangitis in a Male Patient With Concomitant Type 1 Diabetes
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This case report presents the rare case of a male patient with type 1 diabetes recently diagnosed with PBC, and suggests no significant histological, serological, or biochemical differences between PBC in males and females.
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  • Medicine
    Best practice & research. Clinical gastroenterology
  • 2011
TLDR
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Evidence supporting the autoimmune nature of primary biliary cirrhosis includes the appearance of highly specific antimitochondrial antibodies (AMAs) and autoreactive T cells and findings of epidemiological studies and murine models suggest a possible role for exogenous chemicals and infectious agents through molecular mimicry.
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CHAPTER 54 – Primary Biliary Cirrhosis
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References

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Staging of liver biopsy specimens from patients with chronic non-suppurative destructive cholangitis (CNDC) has become an important part of clinical studies that are currently done in many centers, and methods based on uniform criteria that are applicable to all specimens and are easily reproducible are suggested.
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Findings help to clarify the pathogenic mechanism of PBC and suggest that induction may be secondary to a primary response to a xenobiotic that is normally metabolized in an estrogen-dependent pathway.
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Have free times? Read portrait of a killer jack the ripper case closed writer by Why? A best seller book in the world with fantastic worth as well as content is incorporated with fascinating words.
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Serological tests have been used to distinguish between Primary Biliary Cirrhosis and chronic idiopathic obstructive jaundice, which may be extremely difficult to differentiate from obstruction to main bileducts which requires surgical relief.
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TLDR
increasing evidence, including the specific association of AMA with PBC, suggests that AMA is not an epiphenomenon of the disease but plays a significant role in the pathogenesis of PBC.
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TLDR
Knowledge on the structure and putative function of two nuclear autoantigens, the Sp100 and PML proteins, which are present in so-called nuclear dots (NDs) and against which autoantibodies arepresent in a subpopulation of PBC patients are summarized.
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TLDR
Patients with histological features of primary biliary cirrhosis, whether antimitochondrial antibody positive or negative, are quite comparable with respect to clinical and biochemical features.
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TLDR
A group of patients with the clinical and histological features of PBC but who do not fulfil the usual criteria necessary to make this diagnosis are described, believing they are distinct from PBC and have a syndrome of autoimmune cholangitis.
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TLDR
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