The serology of the Addison‐Gull syndrome

  title={The serology of the Addison‐Gull syndrome},
  author={Adrian Reuben},
  • A. Reuben
  • Published 1 January 2003
  • Medicine
  • Hepatology
A Rare Case Presentation: Diagnosing Primary Biliary Cholangitis in a Male Patient With Concomitant Type 1 Diabetes
This case report presents the rare case of a male patient with type 1 diabetes recently diagnosed with PBC, and suggests no significant histological, serological, or biochemical differences between PBC in males and females.
The Discovery of the Hepatitis D Virus: Three Princes of Serendip and the Recognition of Autoantibodies to Liver‐Kidney Microsomes
The allure of CH was that it seemed to be the missing link between cirrhosis and acute hepatitis, and cardiologists now find that serum alkaline phosphatase and gamma-glutamyl transferase are useful in assessing coronary artery disease.
Diagnosis of primary biliary cirrhosis.
  • G. Hirschfield
  • Medicine
    Best practice & research. Clinical gastroenterology
  • 2011
Primary biliary cirrhosis
The autoimmunity of primary biliary cirrhosis and the clonal selection theory
The unique apoptotic features shown for cholangiocytes are the ideal setting for the development of mitochondrial autoantigen presentation to the immune system through macrophages and AMA; thus, turning the non‐traditional mitochondrial antigen into a traditional one.
The liver has a body—A Cook's tour
The physical examination not only has an illustrious pedigree but is still rewarding in hepatology, as it can indicate the presence of liver disease, assess its severity and, together with the patient’s history, give some intuition as to its cause.


Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)
Staging of liver biopsy specimens from patients with chronic non-suppurative destructive cholangitis (CNDC) has become an important part of clinical studies that are currently done in many centers, and methods based on uniform criteria that are applicable to all specimens and are easily reproducible are suggested.
Immunopathogenesis of primary biliary cirrhosis.
Findings help to clarify the pathogenic mechanism of PBC and suggest that induction may be secondary to a primary response to a xenobiotic that is normally metabolized in an estrogen-dependent pathway.
Portrait of a Killer: Jack the Ripper--Case Closed
Have free times? Read portrait of a killer jack the ripper case closed writer by Why? A best seller book in the world with fantastic worth as well as content is incorporated with fascinating words.
Antimitochondrial antibodies in primary biliary cirrhosis.
increasing evidence, including the specific association of AMA with PBC, suggests that AMA is not an epiphenomenon of the disease but plays a significant role in the pathogenesis of PBC.
Autoantibodies against "nuclear dots" in primary biliary cirrhosis.
Knowledge on the structure and putative function of two nuclear autoantigens, the Sp100 and PML proteins, which are present in so-called nuclear dots (NDs) and against which autoantibodies arepresent in a subpopulation of PBC patients are summarized.
Antimitochondrial antibody-negative primary biliary cirrhosis.
Patients with histological features of primary biliary cirrhosis, whether antimitochondrial antibody positive or negative, are quite comparable with respect to clinical and biochemical features.
Antimitochondrial antibody negative primary biliary cirrhosis: a distinct syndrome of autoimmune cholangitis.
A group of patients with the clinical and histological features of PBC but who do not fulfil the usual criteria necessary to make this diagnosis are described, believing they are distinct from PBC and have a syndrome of autoimmune cholangitis.
PBC 95k, a 95-kilodalton nuclear autoantigen in primary biliary cirrhosis.
Affinity-purified antibodies from the 95-kd protein reproduced the nuclear dot immunofluorescence staining pattern, demonstrating that this polypeptide is located in the nuclear dots.
Heterogeneity of antimitochondrial antibodies.