The serology of the Addison‐Gull syndrome

@article{Reuben2003TheSO,
  title={The serology of the Addison‐Gull syndrome},
  author={Adrian Reuben},
  journal={Hepatology},
  year={2003},
  volume={37}
}
  • A. Reuben
  • Published 1 January 2003
  • Medicine
  • Hepatology
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This case report presents the rare case of a male patient with type 1 diabetes recently diagnosed with PBC, and suggests no significant histological, serological, or biochemical differences between PBC in males and females.
The Discovery of the Hepatitis D Virus: Three Princes of Serendip and the Recognition of Autoantibodies to Liver‐Kidney Microsomes
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The allure of CH was that it seemed to be the missing link between cirrhosis and acute hepatitis, and cardiologists now find that serum alkaline phosphatase and gamma-glutamyl transferase are useful in assessing coronary artery disease.
Primary biliary cholangitis: Diagnosis and treatment
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The epidemiology, natural history, predictive and diagnostic features, and current and emerging treatments for Primary biliary cholangitis are reviewed to provide a better understanding of PBC in this patient population.
Diagnosis of primary biliary cirrhosis.
  • G. Hirschfield
  • Medicine
    Best practice & research. Clinical gastroenterology
  • 2011
TLDR
Liver biopsy remains useful in certain settings where clarity is needed to confirm diagnosis, exclude alternative disease, and assess the relative contribution of PBC to other co-existent liver injury, and seeks to demonstrate in particular the classic bile duct lesions, as well as the degree of interface activity.
Primary biliary cirrhosis
TLDR
Evidence supporting the autoimmune nature of primary biliary cirrhosis includes the appearance of highly specific antimitochondrial antibodies (AMAs) and autoreactive T cells and findings of epidemiological studies and murine models suggest a possible role for exogenous chemicals and infectious agents through molecular mimicry.
The autoimmunity of primary biliary cirrhosis and the clonal selection theory
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The unique apoptotic features shown for cholangiocytes are the ideal setting for the development of mitochondrial autoantigen presentation to the immune system through macrophages and AMA; thus, turning the non‐traditional mitochondrial antigen into a traditional one.
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TLDR
Though genetics should be regarded as the major determinant in susceptibility to PBC, several other factors have been proposed, including a history of previous infections, comorbidity with other autoimmune diseases, and lifestyle factors, such as smoking and a high-fat diet.
The liver has a body—A Cook's tour
TLDR
The physical examination not only has an illustrious pedigree but is still rewarding in hepatology, as it can indicate the presence of liver disease, assess its severity and, together with the patient’s history, give some intuition as to its cause.

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