The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

Abstract

T lymphocyte activation is associated with activation of diverse AGC serine kinases (named after family members protein kinase A, protein kinase G and protein kinase C). It has been difficult to assess the function of these molecules in T cell development with simple gene-deletion strategies because different isoforms of AGC kinases are coexpressed in the… (More)
DOI: 10.1038/ni1062

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@article{Hinton2004TheSK, title={The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development}, author={Heather J. Hinton and Dario R Alessi and Doreen A. Cantrell}, journal={Nature Immunology}, year={2004}, volume={5}, pages={539-545} }