The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicans.

@article{Lee2004TheSP,
  title={The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicans.},
  author={Chang-Muk Lee and Andr{\'e} M. Nantel and Linghuo Jiang and Malcolm Whiteway and Shunshan Shen},
  journal={Molecular microbiology},
  year={2004},
  volume={51 3},
  pages={
          691-709
        }
}
SIT4 encodes the multifunctional catalytic subunit of a type 2A-related protein phosphatase of Saccharomyces cerevisiae and has been implicated in cell cycle regulation and nitrogen sensing. We have identified the Candida albicans homologue of SIT4, and we show that its disruption caused a significant reduction in general growth rate, in hyphal outgrowth and in virulence in a mouse infection model. These phenotypes were reversed by the reintroduction of the wild-type SIT4 gene. We used glass… CONTINUE READING
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