The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.

@article{Gnesutta2001TheSK,
  title={The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.},
  author={Nerina Gnesutta and Jia Qu and Audrey Minden},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 17},
  pages={14414-9}
}
The serine/threonine kinase PAK4 was identified first as an effector molecule for the Rho GTPase Cdc42. PAK4 differs from other members of the PAK family both in sequence and function. Previously we have shown that an important function of this kinase is to mediate the induction of filopodia in response to activated Cdc42. Studies with a constitutively active PAK4 mutant have shown that it also has a role in promoting anchorage-independent growth, an important hallmark of oncogenic… CONTINUE READING

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