The serial cultivation of human diploid cell strains.

@article{Hayflick1961TheSC,
  title={The serial cultivation of human diploid cell strains.},
  author={Leonard Hayflick and Paul S. Moorhead},
  journal={Experimental cell research},
  year={1961},
  volume={25},
  pages={585-621}
}
ONLY limited success has been obtained in developing strains of human cells that can be cultivated for long periods of time in vitro and that still preserve the diploid chromosomal configuration [41, 47, 48, 58, 591. Indeed, heteroploidy may be a necessary corollary or even the cause of the alteration of primary or diploid cells in vitro to the status of a cell line. Such changes in chromosome number appear to be independent of the type of primary tissue since they have been observed in cells… CONTINUE READING
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