The serendipitous origin of chordate secretin peptide family members

  title={The serendipitous origin of chordate secretin peptide family members},
  author={Jo{\~a}o C. R. Cardoso and Florbela A Vieira and Ana Paula Soares Gomes and Deborah M. Power},
  booktitle={BMC Evolutionary Biology},
The secretin family is a pleotropic group of brain-gut peptides with affinity for class 2 G-protein coupled receptors (secretin family GPCRs) proposed to have emerged early in the metazoan radiation via gene or genome duplications. In human, 10 members exist and sequence and functional homologues and ligand-receptor pairs have been characterised in representatives of most vertebrate classes. Secretin-like family GPCR homologues have also been isolated in non-vertebrate genomes however their… CONTINUE READING
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