The sera of spontaneously hypertensive rats contain agonistic auto-antibodies against the beta 1-adrenoceptor.

@article{Wallukat1995TheSO,
  title={The sera of spontaneously hypertensive rats contain agonistic auto-antibodies against the beta 1-adrenoceptor.},
  author={Gerd Wallukat and Ingolf E Blasig and Rosemarie Morwinski and Hans. J. Herrmann and Elvira Rohde},
  journal={Journal of hypertension},
  year={1995},
  volume={13 9},
  pages={
          1031-6
        }
}
OBJECTIVE To examine auto-antibodies in the sera of spontaneously hypertensive rats (SHR) and investigate the possibility of abnormalities of the immune system in those rats. DESIGN Blood samples were taken from 18-month-old SHR and age-matched Wistar-Kyoto (WKY) rats. The immunoglobulin fraction was prepared from the rat sera. METHODS Immunoglobulins were investigated in a sensitive biological test system using spontaneously beating neonatal rat heart myocytes. RESULTS Immunoglobulins… CONTINUE READING