The sequential development of abnormal prion protein accumulation in mice with Creutzfeldt-Jakob disease.

@article{Muramoto1992TheSD,
  title={The sequential development of abnormal prion protein accumulation in mice with Creutzfeldt-Jakob disease.},
  author={Tamaki Muramoto and Tetsuyuki Kitamoto and Jun Tateishi and Ikuo Goto},
  journal={The American journal of pathology},
  year={1992},
  volume={140 6},
  pages={1411-20}
}
The distribution and sequential development of prion protein (PrP) accumulation in the central nervous system (CNS) and non-neuronal organs of mice infected with Creutzfeldt-Jakob disease (CJD) were investigated immunohistochemically using a new pretreatment method that greatly enhanced the immunoreactivity of PrP. Prion protein accumulation in the CNS was first detected at 30 days after inoculation and then developed near the inoculation site or periventricular area, and later spread to the… CONTINUE READING

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