The sequence of application of methotrexate and histone deacetylase inhibitors determines either a synergistic or an antagonistic response in childhood acute lymphoblastic leukemia cells

@article{Bastian2011TheSO,
  title={The sequence of application of methotrexate and histone deacetylase inhibitors determines either a synergistic or an antagonistic response in childhood acute lymphoblastic leukemia cells},
  author={Lennart Bastian and Hagen Graf Einsiedel and Gunter Henze and K. H. Seeger and Shabnam Shalapour},
  journal={Leukemia},
  year={2011},
  volume={25},
  pages={359-361}
}
We have acknowledged with great attention the recent article of Leclerc et al. reporting a synergistic cytotoxicity of methotrexate (MTX) and histone deacetylase inhibitors (HDACis) combination treatment in childhood acute lymphoblastic leukemia (ALL) cell lines. Both the group of Leclerc and ours have suggested that the introduction of HDACis into current ALL therapy regimes may provide a promising alternative. Leclerc et al. have observed synergism after sequential treatment with MTX followed… CONTINUE READING
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Effect of More than One Inhibitor

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