The sequence dependence of human nucleotide excision repair efficiencies of benzo[a]pyrene-derived DNA lesions: insights into the structural factors that favor dual incisions.

@article{Kropachev2009TheSD,
  title={The sequence dependence of human nucleotide excision repair efficiencies of benzo[a]pyrene-derived DNA lesions: insights into the structural factors that favor dual incisions.},
  author={Konstantin Y Kropachev and Marina Kolbanovskii and Yuqin Cai and Fabi{\'a}n Rodriguez and Alexander Kolbanovskii and Yang Liu and Lu Fan Zhang and Shantu Amin and Dinshaw J. Patel and Suse Broyde and Nicholas E. Geacintov},
  journal={Journal of molecular biology},
  year={2009},
  volume={386 5},
  pages={1193-203}
}
Nucleotide excision repair (NER) is a vital cellular defense system against carcinogen-DNA adducts, which, if not repaired, can initiate cancer development. The structural features of bulky DNA lesions that account for differences in NER efficiencies in mammalian cells are not well understood. In vivo, the predominant DNA adduct derived from metabolically activated benzo[a]pyrene (BP), a prominent environmental carcinogen, is the 10S (+)-trans-anti-[BP]-N(2)-dG adduct (G*), which resides in the… CONTINUE READING