The septic milieu triggers expression of spliced tissue factor mRNA in human platelets.

Abstract

BACKGROUND Activated platelets have previously-unrecognized mechanisms of post-transcriptional gene expression that may influence hemostasis and inflammation. A novel pathway involves splicing of pre-mRNAs in resting platelets to mature, translatable mRNAs in response to cellular activation. OBJECTIVES We asked if bacterial products and host agonists… (More)
DOI: 10.1111/j.1538-7836.2011.04208.x

Topics

7 Figures and Tables

Slides referencing similar topics