The separate effects of H+ and 2,3-DPG on the oxygen equilibrium curve of human blood.

@article{Samaja1979TheSE,
  title={The separate effects of H+ and 2,3-DPG on the oxygen equilibrium curve of human blood.},
  author={Michele Samaja and Robert M. Winslow},
  journal={British journal of haematology},
  year={1979},
  volume={41 3},
  pages={373-81}
}
Addition of non-saturating amounts of 2,3-DPG (2,3-diphosphoglycerate) within the red cell (2,3-DPG/haemoglobin less than 1) initially reduces Hill's parameter, n. With increasing 2,3-DPG/haemoglobin, n increases until a maximum is reached at 2,3-DPG/haemoglobin greater than 1. Thus, 2-3-DPG influences the shape as well as the position of the whole blood oxygen equilibrium curve (OEC). The importance of this effect on the oxygen carrying capacity of the blood is considered. The effect of 2,3… CONTINUE READING
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