The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability.

@article{McIlwrath2005TheSM,
  title={The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability.},
  author={Sabrina L. McIlwrath and J Hu and Gireesh Anirudhan and J Shin and Gary R Lewin},
  journal={Neuroscience},
  year={2005},
  volume={131 2},
  pages={499-511}
}
Almost all sensory neurons of the dorsal root ganglia have a mechanosensitive receptive field in the periphery. We have shown that the sensitivity to mechanical stimuli of a subset of sensory neurons that are slowly adapting mechanoreceptors (SAM) is strongly dependent on the availability of brain-derived neurotrophic factor (BDNF). Here we have investigated whether the ASIC2 sodium channel, recently shown by us to be necessary for normal SAM sensitivity, might be regulated by BDNF and thus… CONTINUE READING
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