The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors.

  title={The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors.},
  author={Lokesh Dalasanur Nagaprashantha and Rit Vatsyayan and Poorna Chandra Rao Lelsani and Sanjay Awasthi and Sharad S Singhal},
  journal={International journal of cancer},
  volume={128 4},
Normal cells continuously monitor the nature of their respective cellular microenvironment. They are equipped with an inherent molecular defense to detect changes that can precipitate and trigger an oncogenic cascade in the internal and external environment of cells. The process called anoikis unleashes many a characteristic molecular change in the cells which eventually program to cell death in response to cell detachment and inappropriate cellular attachment, both of which can otherwise… CONTINUE READING


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