The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa.

  title={The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa.},
  author={W. James Gooderham and Shaan Gellatly and François Sanschagrin and Joseph B. McPhee and Manjeet Bains and C{\'e}line Cosseau and Roger C. L{\'e}vesque and Robert E. W. Hancock},
  volume={155 Pt 3},
Pseudomonas aeruginosa is a ubiquitous environmental Gram-negative bacterium that is also a major opportunistic human pathogen in nosocomial infections and cystic fibrosis chronic lung infections. PhoP-PhoQ is a two-component regulatory system that has been identified as essential for virulence and cationic antimicrobial peptide resistance in several other Gram-negative bacteria. This study demonstrated that mutation of phoQ caused reduced twitching motility, biofilm formation and rapid… 

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