The sensitizing capacity of helenin and of two of its main constituents, the sesquiterpene lactones alantolactone and isoalantolactone: a comparison of epicutaneous and intradermal sensitizing methods in different strains of guinea pig.

@article{Stampf1982TheSC,
  title={The sensitizing capacity of helenin and of two of its main constituents, the sesquiterpene lactones alantolactone and isoalantolactone: a comparison of epicutaneous and intradermal sensitizing methods in different strains of guinea pig.},
  author={J. L. Stampf and Claude Benezra and G. Klecak and Horst Geleick and Karl Heinz Schulz and Bernard A. Hausen},
  journal={Contact dermatitis},
  year={1982},
  volume={8 1},
  pages={
          16-24
        }
}
The sensitizing capacities of helenin (an extract from a Compositae Inula helenium L.), alantolactone and isoalantolactone (two isomeric sesquiterpene lactones), were assessed by sensitizing guinea pigs of different strains: albino Himalayan spotted, Pirbright and Hartley. Both alantolactone and isoalantolactone are found to be sensitizers if injected intradermally. Only Pirbright guinea pigs showed a high sensitization rate by the open epicutaneous technique; with this method, alantolactone… CONTINUE READING