The sensitization of glioma cells to cisplatin and tamoxifen by the use of catechin

@article{Shervington2008TheSO,
  title={The sensitization of glioma cells to cisplatin and tamoxifen by the use of catechin},
  author={A. Shervington and V. Pawar and Sharad Menon and Dipti Thakkar and R. Patel},
  journal={Molecular Biology Reports},
  year={2008},
  volume={36},
  pages={1181-1186}
}
Telomerase expression strongly correlates with the grade of malignancy in glioma with inhibition illustrating a definite increase in chemosensitivity. This study was designed to investigate the effects of a green tea derivative, epigallocatechin-3-gallate (EGCG); together with either cisplatin or tamoxifen in glioma, and to investigate whether these effects are mediated through telomerase suppression. EGCG showed a significant cytotoxic effect on 1321N1 cells after 24 h and on U87-MG cells… Expand
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