The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study

@article{Bone2007TheSO,
  title={The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study},
  author={Wilhelm Bone and Charlotte M. Walden and Martin Fritsch and Ulrike Voigtmann and Eckhard Leifke and Ulrich Gottwald and Stephanie D. Boomkamp and Frances M. Platt and Aarnoud C van der Spoel},
  journal={Reproductive Biology and Endocrinology},
  year={2007},
  volume={5},
  pages={1 - 1}
}
BackgroundA major event in the post-meiotic development of male germ cells is the formation of the acrosome. This process can be perturbed in C57BL/6 mice by administration of the small molecule miglustat (N-butyldeoxynojirimycin, NB-DNJ). The miglustat-treated mice produce morphologically abnormal spermatozoa that lack acrosomes and are poorly motile. In C57BL/6 mice, miglustat can be used to maintain long-term reversible infertility. In contrast, when miglustat was evaluated in normal men, it… CONTINUE READING

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