The sense of smell: genomics of vertebrate odorant receptors.

  title={The sense of smell: genomics of vertebrate odorant receptors.},
  author={Janet M Young and Barbara J. Trask},
  journal={Human molecular genetics},
  volume={11 10},
Olfactory receptor (OR) proteins interact with odorant molecules in the nose, initiating a neuronal response that triggers the perception of a smell. The OR family is one of the largest known mammalian gene families, with around 900 genes in human and 1500 in mouse. After discounting pseudogenes, the functional repertoire in mouse is more than three times larger than that of human. OR genes encode G-protein-coupled receptors containing seven transmembrane domains. ORs are arranged in clusters… CONTINUE READING
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