The self-renewing mechanism of stem cells in the germline.

  title={The self-renewing mechanism of stem cells in the germline.},
  author={Haifan Lin},
  journal={Current opinion in cell biology},
  volume={10 6},
  • Haifan Lin
  • Published 1998 in Current opinion in cell biology
Germline stem cells (GSCs) are a self-renewing population of germ cells that serve as the source of gametes in diverse organisms. Current research suggests that the self-renewing division of GSCs is controlled both by somatic signaling and by intracellular mechanisms such as differential gene expression, asymmetric cytoskeletal organization, and the cell cycle machinery. These findings provide a framework for the further study of GSCs and stem cell renewal in general.