The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues.

@article{Terentis2010TheSD,
  title={The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues.},
  author={Andrew C Terentis and Mohammed Freewan and Tito S Semp{\'e}rtegui Plaza and Mark J. Raftery and Roland Stocker and Shane Ross Thomas},
  journal={Biochemistry},
  year={2010},
  volume={49 3},
  pages={591-600}
}
The heme enzyme indoleamine 2,3-dioxygenase (IDO) plays an important immune regulatory role by catalyzing the oxidative degradation of l-tryptophan. Here we show that the selenezal drug ebselen is a potent IDO inhibitor. Exposure of human macrophages to ebselen inhibited IDO activity in a manner independent of changes in protein expression. Ebselen inhibited the activity of recombinant human IDO (rIDO) with an apparent inhibition constant of 94 +/- 17 nM. Optical and resonance Raman… CONTINUE READING

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