The selectivity of newly synthesized ergot derivatives to alpha 1- and alpha 2-adrenoceptors, D1- and D2-dopaminergic receptors, muscarinic acetylcholinoceptors and beta-adrenoceptors.

@article{Okumura1988TheSO,
  title={The selectivity of newly synthesized ergot derivatives to alpha 1- and alpha 2-adrenoceptors, D1- and D2-dopaminergic receptors, muscarinic acetylcholinoceptors and beta-adrenoceptors.},
  author={Katsuhiko Okumura and Katsuo Koike and Hiroshi Asai and Issei Takayanagi},
  journal={General pharmacology},
  year={1988},
  volume={19 3},
  pages={463-6}
}
1. We tested affinities of newly synthesized ergot derivatives to alpha 1- and alpha 2-adrenoceptors, D1- and D2-dopamine receptors, muscarinic acetylcholinoceptors and beta-adrenoceptors using radioligand binding techniques. 2. BAM-1110 was alpha 2-selective, though its affinity to alpha 2-adrenoceptors was one tenth less than that of yohimbine. 3. BAM-1303, which was non-selective, had high affinity to alpha-adrenoceptors. The pKi-values for BAM-1303 was 10.11 against both [3H]prazosin (alpha… CONTINUE READING