The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats.

@article{Matuszcyk1998TheSS,
  title={The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats.},
  author={J Vega Matuszcyk and Knut Larsson and Ejnar Eriksson},
  journal={Pharmacology, biochemistry, and behavior},
  year={1998},
  volume={60 2},
  pages={527-32}
}
A male rat put in an open-field arena in which it is free to spend time in the vicinity of--but not in contact with--an estrous female, or in the vicinity of a male, usually spends more time with the female than with the male or elsewhere. Tentatively, the percentage of time spent in the vicinity of the female in this paradigm may be regarded as a measure of sexual motivation. In humans, treatment with selective serotonin reuptake inhibitors (SSRIs) may cause reduced libido. To investigate to… CONTINUE READING

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