The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms

@article{Sindrup1990TheSS,
  title={The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms},
  author={S{\o}ren H Sindrup and Lars Freng Gram and Kim Br{\o}sen and Ole Esh{\o}j and Erik F. Mogensen},
  journal={Pain},
  year={1990},
  volume={42},
  pages={135-144}
}
The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy
TLDR
Compared with earlier results obtained with imipramine administered on the basis of plasma level monitoring, citalopram appeared to be less effective, but seemed to be better tolerated.
Paroxetine. A review of its pharmacology, therapeutic use in depression and therapeutic potential in diabetic neuropathy.
TLDR
Paroxetine appears to be a more attractive option than tricyclic antidepressants for the treatment of depression in late life because of its better tolerability profile and potentially lower toxicity in overdosage and in patients with cardiovascular disease.
Lack of effect of mianserin on the symptoms of diabetic neuropathy
TLDR
In contrast to drugs with documented effects on the symptoms of diabetic neuropathy, mianserin has a very weak or no inhibitory effect on 5-HT and noradrenaline reuptake and this may explain its poor clinical effect.
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
TLDR
Desipramine relieves pain caused by diabetic neuropathy with efficacy similar to that of amitriptyline, offering an alternative for patients unable to tolerate the latter and blockade of norepinephrine reuptake is likely to mediate the analgesic effect of these antidepressant drugs in diabetic Neuropathy.
Concentration‐response relationship in imipramine treatment of diabetic neuropathy symptoms
TLDR
The dose‐dependent kinetics of imipramine was confirmed, and dose increments should be carried out in small steps and preferably with monitoring of drug levels, and the effect of treatment was evaluated by use of visual analog scales.
Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensity
Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double-blind cross-over study.
TLDR
Compared with earlier results obtained with imipramine dosed on the basis of plasma level monitoring, clomipramines on fixed doses appeared less efficacious whereas the side effect profiles were the same.
Paroxetine: a review of its pharmacology, pharmacokinetics and utility in the treatment of a variety of psychiatric disorders.
  • W. Heydorn
  • Medicine, Psychology
    Expert opinion on investigational drugs
  • 1999
TLDR
The efficacy seen in short-term studies with paroxetine in the treatment of depression is maintained when the drug is given chronically, and the compound shows efficacy superior to placebo, and similar to that obtained with standard tricyclic or tetracyclic agents.
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References

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TLDR
The results indicate that aldose reductase inhibitor treatment may be of value in diabetic polyneuropathy, and provide support for the sorbitol pathway hypothesis of diabetic polyNEuropathy.
Pain Relief in Diabetic Neuropathy: The Effectiveness of Imipramine and Related Drugs
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  • Medicine, Psychology
    Diabetic medicine : a journal of the British Diabetic Association
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TLDR
Experience of treating 80 consecutive patients with painful diabetic neuropathy and a double‐blind study of imipramine in acute painful neuropathy are reported, suggesting a peripheral rather than central drug action.
A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy.
TLDR
There is no justification for the use of these agents in the treatment of painful neuropathy outside of large, controlled clinical trials, according to a reevaluation of previous trials.
Effects of sorbinil therapy in diabetic patients with painful peripheral neuropathy and autonomic neuropathy.
TLDR
The changes in both expiration-inspiration ratios and resting minimal heart rate are consistent with a sorbinil-related improvement in cardiac parasympathetic nerve function, as indicated by unaltered glycohemoglobin levels.
Imipramine treatment of painful diabetic neuropathy.
TLDR
The rating of specific symptoms at the end of each treatment period showed a beneficial effect of imipramine on pain, paresthesia, dysesthesia, numbness, and nocturnal aggravation.
Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood
TLDR
It is concluded that amitriptyline relieves pain in diabetic neuropathy; this effect is independent of mood elevation.
Imipramine metabolites in blood of patients during therapy and after overdose
TLDR
The patients with very low hydroxymetabollte levels had considerably higher desipramine levels than the others, indicating that the low metabolite levels were due to poor hydroxylation, and in the patients on continuous ImipRAMine treatment, the steady‐state levels of 2‐OH‐imipramin and 2‐ OH‐desipramines were very low or immeasurable in five patients.
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