The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms

@article{Sindrup1990TheSS,
  title={The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms},
  author={S{\o}ren H Sindrup and Lars Freng Gram and Kim Br{\o}sen and Ole Esh{\o}j and Erik F. Mogensen},
  journal={Pain},
  year={1990},
  volume={42},
  pages={135-144}
}
&NA; The effect of the selective serotonin reuptake inhibitor paroxetine on diabetic neuropathy symptoms was examined in comparison to imipramine and placebo in a randomised, double‐blind, cross‐over study. Paroxetine was given as a fixed dose of 40 mg/day, while the dose of imipramine was adjusted to yield optimal plasma levels of imipramine plus desipramine of 400–600 nM. Paroxetine significantly reduced the symptoms of neuropathy as measured by both observer‐ and self‐rating, but was… Expand
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  • Expert opinion on investigational drugs
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The efficacy seen in short-term studies with paroxetine in the treatment of depression is maintained when the drug is given chronically, and the compound shows efficacy superior to placebo, and similar to that obtained with standard tricyclic or tetracyclic agents. Expand
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