• DOI:10.1016/0304-3959(90)91157-E
Corpus ID: 42327989

The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms

@article{Sindrup1990TheSS,
  title={The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms},
  author={S. Sindrup and L. F. Gram and K. Br{\o}sen and O. Esh{\o}j and E. Mogensen},
  journal={Pain},
  year={1990},
  volume={42},
  pages={135-144}
}

S. Sindrup, L. F. Gram, +2 authors E. Mogensen

Published 1990

Medicine

Pain

&NA; The effect of the selective serotonin reuptake inhibitor paroxetine on diabetic neuropathy symptoms was examined in comparison to imipramine and placebo in a randomised, double‐blind, cross‐over study. Paroxetine was given as a fixed dose of 40 mg/day, while the dose of imipramine was adjusted to yield optimal plasma levels of imipramine plus desipramine of 400–600 nM. Paroxetine significantly reduced the symptoms of neuropathy as measured by both observer‐ and self‐rating, but was… CONTINUE READING

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