The selective norepinephrine reuptake inhibitor, LY368975, reduces food consumption in animal models of feeding.

@article{Gehlert1998TheSN,
  title={The selective norepinephrine reuptake inhibitor, LY368975, reduces food consumption in animal models of feeding.},
  author={Donald R. Gehlert and Laura J. Dreshfield and F Tinsley and Mark J. Benvenga and S. Gleason and Ray W. Fuller and David T. Wong and Susan K. Hemrick-Luecke},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={287 1},
  pages={122-7}
}
The compound, LY368975 ((R)-thionisoxetine) is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. We evaluated the in vivo properties of LY368975 in various animal models. In mice, LY368975 prevented heart NE depletion by 6-hydroxydopamine with an ED50 of 1.22 mg/kg. In rats, orally administered LY368975 inhibited 3H-NE uptake into hypothalamic synaptosomes ex vivo with an ED50 of 2.5 mg/kg and 3H-tomoxetine binding to the NE transporter with an ED50 of 2.7 mg/kg. When… CONTINUE READING