The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats.

@article{Carmo2009TheSN,
  title={The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats.},
  author={Gail Pereira Do Carmo and John E. Folk and Kenner C. Rice and Elena H. Chartoff and William A Carlezon and S. Stevens Negus},
  journal={European journal of pharmacology},
  year={2009},
  volume={604 1-3},
  pages={
          58-65
        }
}
Delta opioid receptor agonists are under development for a variety of clinical applications, and some findings in rats raise the possibility that agents with this mechanism have abuse liability. The present study assessed the effects of the non-peptidic delta opioid agonist SNC80 in an assay of intracranial self-stimulation (ICSS) in rats. ICSS was examined at multiple stimulation frequencies to permit generation of frequency-response rate curves and evaluation of curve shifts produced by… CONTINUE READING

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