The selective inhibition of hippocampal glutamic acid decarboxylase in zinc-induced epileptic seizures

@article{Itoh1982TheSI,
  title={The selective inhibition of hippocampal glutamic acid decarboxylase in zinc-induced epileptic seizures},
  author={Masatoshi Itoh and Manuchair Ebadi},
  journal={Neurochemical Research},
  year={1982},
  volume={7},
  pages={1287-1298}
}
The intracerebroventricular administration of Zn2+ (0.3 μmol/10 μl) causes epileptic seizures characterized by running fits, jumping, vocalization, fasiculation of facial muscles, myoclonic movements of the limbs and tonic-clonic convulsions. These episodes are blocked or reversed by γ-aminobutyric acid (0.4 μmol/10 μl). When assayed under conditions where pyridoxal phosphate was not added, the activity of glutamic acid decarboxylase decreased significantly in hippocampus from 18.9 to 15.3 and… CONTINUE READING
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Zinc binding proteins in rat brain and their interactions with glutamic acid decarboxylase

  • M. ITOH, M. EBADI
  • 1982
1 Excerpt

Neurotransmitters, Seizures and Epilepsy

  • P. L. MORSELLI, K. G. LLOYD, W. LGSCHER, B. MELDRUM, E. H. REYNOLDS
  • 1981

The role of Zn ++ in pyridoxal phosphate mediated regulation of glutamic acid decarboxylase in brain

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  • Int. J. Biochem
  • 1981
2 Excerpts

The selective inhibition of glutamic acid decarboxylase (GAD) in hippocampus by Zn ++

  • M. ITO, M. EBADI
  • Pharmacologist
  • 1981
1 Excerpt

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