The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells.

@article{Cohen1999TheSD,
  title={The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells.},
  author={George B Cohen and Rajesh T Gandhi and Daniel M Davis and Ofer Mandelboim and Benjamin K Chen and Jack Leonard Strominger and David Baltimore},
  journal={Immunity},
  year={1999},
  volume={10 6},
  pages={
          661-71
        }
}
To avoid detection by CTL, HIV encodes mechanisms for removal of class I MHC proteins from the surface of infected cells. However, class I downregulation potentially exposes the virus-infected cell to attack by NK cells. Human lymphoid cells are protected from NK cell cytotoxicity primarily by HLA-C and HLA-E. We present evidence that HIV-1 selectively downregulates HLA-A and HLA-B but does not significantly affect HLA-C or HLA-E. We then identify the residues in HLA-C and HLA-E that protect… CONTINUE READING

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