The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

  title={The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1},
  author={M. Asaliaru Komatsu and Hirofumi Kurokawa and Satoshi Waguri and Keiko Taguchi and Akira Kobayashi and Yoshinobu Ichimura and Yu-shin Sou and Izumi Ueno and Ayako Sakamoto and Kit I. Tong and Mihee Kim and Yasumasa Nishito and Shun-ichiro Iemura and Tohru Natsume and Takashi Ueno and Eiki Kominami and Hozumi Motohashi and Keiji Tanaka and Masayuki Yamamoto},
  journal={Nature Cell Biology},
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These phenotypes correspond closely to the pathological conditions seen in human liver diseases, including alcoholic hepatitis and hepatocellular carcinoma. However, the molecular mechanisms and pathophysiological processes in these events are still unknown. Here we report the identification of a novel regulatory mechanism by… CONTINUE READING
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