Corpus ID: 192177

The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds.

@article{Fariss1994TheSA,
  title={The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds.},
  author={Marc W. Fariss and M B Fortuna and Carleen K. Everett and John D. Smith and D. F. Trent and Zora Djuric},
  journal={Cancer research},
  year={1994},
  volume={54 13},
  pages={
          3346-51
        }
}
  • Marc W. Fariss, M B Fortuna, +3 authors Zora Djuric
  • Published in Cancer research 1994
  • Biology, Medicine
  • In the present study we have established that the antitumor activity of alpha-tocopheryl succinate (TS, vitamin E succinate) and cholesteryl succinate (CS) result from the action of the intact TS and CS compounds and not from the release of alpha-tocopherol, cholesterol, or succinate. We report that treatment of murine leukemia cell lines C1498 (myeloid) and L1210 (lymphocytic), with the tris salts of TS or CS, but not alpha-tocopherol and tris succinate or cholesterol and tris succinate… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 45 CITATIONS

    Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo.

    • Tobias Weber, Min Lu, +13 authors Jiri Neuzil
    • Biology, Medicine
    • Clinical cancer research : an official journal of the American Association for Cancer Research
    • 2002
    VIEW 8 EXCERPTS
    CITES RESULTS & BACKGROUND

    Novel dual VES phospholipid self-assembled liposomes with an extremely high drug loading efficiency.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Methodological problems with population cancer studies: The forgotten confounding factors

    VIEW 1 EXCERPT
    CITES BACKGROUND