The selective PDE5 inhibitor, sildenafil, improves object memory in Swiss mice and increases cGMP levels in hippocampal slices.

@article{Rutten2005TheSP,
  title={The selective PDE5 inhibitor, sildenafil, improves object memory in Swiss mice and increases cGMP levels in hippocampal slices.},
  author={Kris Rutten and Jan de Vente and Attila S{\'i}k and Marjanne Markerink-van Ittersum and Jos Prickaerts and Arjan Blokland},
  journal={Behavioural brain research},
  year={2005},
  volume={164 1},
  pages={11-6}
}
Previous studies have shown memory enhancing effects of phosphodiesterase type 5 (PDE5) inhibitors in rats. However, differences in nitric oxide (NO)-mediated cyclic GMP (cGMP) signaling in the hippocampus have been described between rats and mice. In the present study we investigated the memory enhancing effects of the PDE5 inhibitor, sildenafil on memory performance in Swiss mice using the object recognition task. Sildenafil (0.3, 1 and 3 mg/kg) was administered orally directly after the… CONTINUE READING
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