The selective A2A receptor antagonist SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat.

@article{Melani2003TheSA,
  title={The selective A2A receptor antagonist SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat.},
  author={Alessia Melani and Leonardo Pantoni and Francesca Bordoni and Marco Gianfriddo and Loria Bianchi and Maria Giuliana Vannucchi and Rosalia Bertorelli and Angela Monopoli and Felicita Pedata},
  journal={Brain research},
  year={2003},
  volume={959 2},
  pages={243-50}
}
Adenosine A(2A) receptor antagonists have been proved protective in different ischemia models. In this study we verified if the protective effect of the selective A(2A) antagonist, SCH 58261, could be attributed to the reduction of the excitatory amino acid outflow induced by cerebral focal ischemia. A vertical microdialysis probe was inserted into the striatum of male Wistar rats and, after 24 h, permanent right intraluminal middle cerebral artery occlusion (MCAo) was induced. Soon after… CONTINUE READING

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