The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice

@article{Odland2021TheS5,
  title={The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice},
  author={Anna U Odland and Jesper L. Kristensen and Jesper T. Andreasen},
  journal={Behavioural Pharmacology},
  year={2021},
  volume={32},
  pages={448 - 452}
}
Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are showing promise in the treatment of psychiatric disorders, such as treatment-resistant depression and anxiety. Human studies suggest that enhanced cognitive flexibility may contribute to their clinical efficacy. Both improvement and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the link between 5-HT2AR pharmacology and cognitive flexibility equivocal. We tested the selective 5-HT2AR agonist… 
Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder
TLDR
Findings suggest a nuanced relationship between cognitive and neural flexibility, whereas some enduring increases in neural dynamics may allow for shifting out of a maladaptively rigid state, larger persisting increases in Neural dynamics may be of less benefit to psilocybin therapy.

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