The selective 5-HT1A receptor agonist repinotan HCl attenuates histopathology and spatial learning deficits following traumatic brain injury in rats

@article{Kline2001TheS5,
  title={The selective 5-HT1A receptor agonist repinotan HCl attenuates histopathology and spatial learning deficits following traumatic brain injury in rats},
  author={Anthony E. Kline and J. H. Yu and Ervin Horv{\'a}th and Donald W. Marion and C E Dixon},
  journal={Neuroscience},
  year={2001},
  volume={106},
  pages={547-555}
}
The selective 5-HT1A receptor agonist Repinotan HCl (BAY x3702) has been reported to attenuate cortical damage and improve functional performance in experimental models of cerebral ischemia and acute subdural hematoma. Using a clinically relevant contusion model of traumatic brain injury, we tested the hypothesis that a 4-h continuous infusion of Repinotan HCl (10 μg/kg/h i.v.) commencing 5 min post-injury would ameliorate functional outcome and attenuate histopathology. Forty isoflurane… 
Traumatic brain injury-induced cognitive and histological deficits are attenuated by delayed and chronic treatment with the 5-HT1A-receptor agonist buspirone.
TLDR
Data indicate that BUS has a narrow therapeutic dose response, and that 0.3 mg/kg is optimal for enhancing spatial learning and memory in this model of TBI.
Neuroprotective Efficacy of Repinotan HCl, a 5-HT1A Receptor Agonist, in Animal Models of Stroke and Traumatic Brain Injury
  • F. Mauler, E. Horváth
  • Medicine
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  • 2005
TLDR
The favorable neuroprotective efficacy, broad dose–response curve, and prolonged therapeutic window observed in all models strongly suggest that repinotan is a promising candidate for treating acute ischemic stroke in humans.
NMDA receptor antagonist MK-801 reduces neuronal damage and preserves learning and memory in a rat model of traumatic brain injury
TLDR
Impairment in learning and memory in TBI animals could be repaired by treatment with MK-801, which could significantly inhibit the degeneration and apoptosis of neurons in damaged brain areas.
A delayed and chronic treatment regimen with the 5-HT1A receptor agonist 8-OH-DPAT after cortical impact injury facilitates motor recovery and acquisition of spatial learning
TLDR
Findings from the laboratory showing that 8-OH-DPAT improves neurobehavior after TBI are extended by demonstrating that the benefits can be achieved even when treatment is withheld for 24h, and a delayed and chronic treatment regimen may be more clinically feasible.
A review of the neuroprotective properties of the 5-HT1A receptor agonist repinotan HCl (BAYx3702) in ischemic stroke.
TLDR
The dose- and time-dependent neuroprotective efficacy of repinotan indicates that the drug is a promising candidate for prevention of secondary brain damage in brain-injured patients suffering from acute ischemic stroke, however, the first, randomized, double blind, placebo-controlled clinical trial did not demonstrate the efficacy of the drug.
Acute treatment with the 5-HT1A receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma
TLDR
Previous results from the laboratory showing that both a single systemic administration of 8-OH-DPAT and EE improve recovery after TBI are replicated and findings are extended by elucidating that the combination of treatments in this particular paradigm did not confer additional benefit.
Protective effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rats
TLDR
The administration of 8-OH-DPAT attenuated spatial acquisition deficits and reduced hippocampal CA(3) cell loss vs. vehicle and augment published reports that 5-HT(1A) receptor agonists confer neuroprotective effects after experimental TBI.
Elucidating the role of 5-HT1A and 5-HT7 receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury
8-OH-DPAT is a 5-HT(1A/7) receptor agonist that enhances behavioral recovery after traumatic brain injury (TBI). This study is a first attempt to decipher whether the benefits induced by 8-OH-DPAT
Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury.
TLDR
It is suggested that a combined therapeutic regimen of 8-OH-DPAT and EE reduces TBI-induced ChAT(+) cell loss, but does not enhance hippocampal cell survival or neurobehavioral performance beyond that of either treatment alone.
Neuroprotective effects of MK-801 against traumatic brain injury in immature rats
TLDR
Histopathological and immunohistochemical evaluations showed that acute treatment of MK-801 has a neuroprotective role against trauma induced hippocampal neuron loss and associated cognitive impairment in immature rats.
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