The selective σ2 ligand Lu 28‐179 has an antidepressant‐like profile in the rat chronic mild stress model of depression

@article{Snchez2000TheS,
  title={The selective $\sigma$2 ligand Lu 28‐179 has an antidepressant‐like profile in the rat chronic mild stress model of depression},
  author={Connie S{\'a}nchez and Mariusz Papp},
  journal={Behavioural Pharmacology},
  year={2000},
  volume={11},
  pages={117-124}
}
The selective sigma2 (σ2) ligand Lu 28‐179, or 1′‐[4[1‐(4‐fluorophenyl)‐1 H ‐indol‐3‐yl]‐1‐butyl]spiro[isobenzofuran‐1(3H),4′‐piperidine], was studied in the chronic mild stress (CMS) model of depression. The CMS test procedure consists of sequential exposures to a variety of mild stressors for a prolonged period of time and results in behavioural hedonic deficits, which can be measured as decreased consumption of a palatable sucrose solution. In rats, exposure to CMS treatment with citalopram… 
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