• DOI:10.1097/00008877-200004000-00003
• Corpus ID: 22007769

The selective σ2 ligand Lu 28‐179 has an antidepressant‐like profile in the rat chronic mild stress model of depression

@article{Snchez2000TheS,
  title={The selective $\sigma$2 ligand Lu 28‐179 has an antidepressant‐like profile in the rat chronic mild stress model of depression},
  author={Connie S{\'a}nchez and Mariusz Papp},
  journal={Behavioural Pharmacology},
  year={2000},
  volume={11},
  pages={117-124}
}

• C. Sánchez, M. Papp
• Published 1 April 2000
• Psychology, Biology
• Behavioural Pharmacology

The selective sigma2 (σ2) ligand Lu 28‐179, or 1′‐[4[1‐(4‐fluorophenyl)‐1 H ‐indol‐3‐yl]‐1‐butyl]spiro[isobenzofuran‐1(3H),4′‐piperidine], was studied in the chronic mild stress (CMS) model of depression. The CMS test procedure consists of sequential exposures to a variety of mild stressors for a prolonged period of time and results in behavioural hedonic deficits, which can be measured as decreased consumption of a palatable sucrose solution. In rats, exposure to CMS treatment with citalopram or imipramine for 2 or 4 weeks, respectively, normalized the sucrose intake. Similarly, Lu 28‐179 (1.0 mg/kg subcutaneously per day) normalized sucrose intake in rats exposed to CMS. This effect was found in two separate experiments and was achieved after 3 and 4 weeks of treatment, respectively. This suggests an antidepressant potential for Lu 28‐179. Doses of 0.01 and 0.1 mg/kg were inactive. Groups exposed to CMS and treated with 0.5, 2.0 or 3.0 mg/kg showed a significantly increased sucrose intake compared with vehicle‐treated stressed animals at week 5. However, this effect was confounded by decreased intake in the vehicle controls. Lu 28‐179 did not affect sucrose intake in non‐stressed rats at any of the doses tested.