The selection of the α,β heterodimeric T-cell receptor for antigen.

T cells express α,β heterodimeric receptor proteins which are involved in the MHC-restricted binding of antigen (1,2). The nucleotide sequences of T-cell receptor genes(3-6) have not provided an obvious explanation for the 'MHC-ness' of T-cell specificity or the different specificity of T-cell subsets. The binding of α,β heterodimeric T-cell receptors has… CONTINUE READING