The selectins: vascular adhesion molecules.

  title={The selectins: vascular adhesion molecules.},
  author={Thomas F. Tedder and Douglas A. Steeber and Andrea L Chen and Pablo Engel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={9 10},
The selectin family of adhesion molecules mediates the initial attachment of leukocytes to venular endothelial cells before their firm adhesion and diapedesis at sites of tissue injury and inflammation. The selectin family consists of three closely related cell-surface molecules with differential expression by leukocytes (L-selectin), platelets (P-selectin), and vascular endothelium (E- and P-selectin). The selectins have characteristic extracellular regions composed of an amino-terminal lectin… CONTINUE READING
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