The selecting: vascular adhesion molecules

@article{Tedder1995TheSV,
  title={The selecting: vascular adhesion molecules},
  author={Thomas F. Tedder and Douglas A. Steeber and Anjun Chen and Pablo Engel},
  journal={The FASEB Journal},
  year={1995},
  volume={9},
  pages={866 - 873}
}
The selectin family of adhesion molecules mediates the initial attachment of leukocytes to venular endothelial cells before their firm adhesion and diapedesis at sites of tissue injury and inflammation. The selectin family consists of three closely related cell‐surface molecules with differential expression by leukocytes (L‐eelectin), platelets (P‐se‐lectin), and vascular endothelium (E‐ and P‐selectin). The selecting have characteristic extracellular regions composed of an amino‐terminal… Expand
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The differential expression and function of the selectins by various leukocytes subclasses and diverse beds of vascular endothelium allows for considerable specificity in leukocyte migration into tissues at sites of inflammation, wound healing, and immune responses. Expand
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Convincing data have been published supporting the idea that selectins and glycoprotein ligands of the selectins participate in the activation of leukocyte integrins. Expand
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TLDR
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  • Biology, Medicine
  • Cardiovascular research
  • 1996
TLDR
The paradigm of neutrophil recruitment is presented to serve as a model for the recruitment mechanisms of other inflammatory cells. Expand
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The role of cell adhesion molecules in mediating endothelial cell function is discussed, from how their different physiochemical properties contribute to function, to how specific ligand interactions expressed on leukocyte cell populations contribute to functions ranging from constitutive cell trafficking to inflammation. Expand
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Characteristic features of the inflammatory and immune responses involve the recruitment of leukocytes to sites of tissue injury and the recirculation of lymphocytes through hematopoietic andExpand
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  • Chemistry, Medicine
  • Advances in experimental medicine and biology
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TLDR
To fulfill this role successfully, the neutrophil must be able to migrate from the blood into the area of inflammation, a process which involves activation of endothelial cells and leukocyte by inflammatory stimuli, adherence to the endothelial surface at the site of inflammation and migration through endothelium to extravascular tissue. Expand
Immunohistochemical Analysis of Adhesion Molecules in Airway Biopsies
Adhesion molecules are receptors found on the surface of leukocytes and endothelial cells, which bind to their ligands, either on other cells or on the extracellular matrix. The function of adhesionExpand
[The role of adhesion molecules in cutaneous inflammation].
  • T. Kadono
  • Chemistry, Medicine
  • Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology
  • 2010
TLDR
Manipulating adhesion molecules might lead to novel therapy to treat dermatitis by controlling leukocytes migration into cutaneous sites of inflammation. Expand
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