The secretory actions of histamine in rat small intestine.

  title={The secretory actions of histamine in rat small intestine.},
  author={Johnny Hardcastle and P. T. Hardcastle},
  journal={The Journal of physiology},
1. Histamine caused a dose-dependent rise in the transintestinal potential difference in vivo that was competitively blocked by H1, but not by H2 antagonists. This effect of histamine was also reduced by the cyclo-oxygenase inhibitor indomethacin. 2. Histamine induced a net secretion of fluid by the small intestine and this effect was reduced by indomethacin. 3. In intestinal sheets histamine increased the potential difference, short-circuit current and tissue resistance. This response was… CONTINUE READING