The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth.

@article{Rhee2005TheSG,
  title={The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth.},
  author={David K. Rhee and Jos{\'e} Marcelino and M. Baker and Yaoqin Gong and Patrick Smits and V{\'e}ronique Lefebvre and Gregory D. Jay and Matthew Stewart and Hongwei Wang and Matthew L Warman and John D. Carpten},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 3},
  pages={
          622-31
        }
}
The long-term integrity of an articulating joint is dependent upon the nourishment of its cartilage component and the protection of the cartilage surface from friction-induced wear. Loss-of-function mutations in lubricin (a secreted glycoprotein encoded by the gene PRG4) cause the human autosomal recessive disorder camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). A major feature of CACP is precocious joint failure. In order to delineate the mechanism by which lubricin protects… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome

Jeffrey M. Trent, Matthew L. Warman, +22 authors Sultan A. Bahabri
  • Nature Genetics
  • 1999
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

The camptodactylyarthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1. Arthritis

Bahabri, S.A
  • 1998
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

How Many Steps / Day Are Enough ? Preliminary Pedometer Indices for Public Health

Catrine Tudor-Locke, David R. Bassett
  • 2004
VIEW 2 EXCERPTS

Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon.

  • Matrix biology : journal of the International Society for Matrix Biology
  • 2002
VIEW 1 EXCERPT