The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects.

@article{Shimozato2006TheSF,
  title={The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects.},
  author={Osamu Shimozato and Shin-ichi Ugai and Masako Chiyo and Hisanori Takenobu and Hiroyasu Nagakawa and Akihiko Wada and Kiyoko Kawamura and Hiroshi Yamamoto and Masatoshi Tagawa},
  journal={Immunology},
  year={2006},
  volume={117 1},
  pages={22-8}
}
Interleukin (IL)-23 is a heterodimeric cytokine consisting of a novel p19 molecule and the p40 subunit of IL-12. Since secreted p40 can act as an antagonist for IL-12, we investigated whether p40 also inhibited IL-23-mediated immunological functions. p40 did not induce interferon (IFN)-gamma or IL-17 production from splenocytes but impaired IL-23-induced cytokine production by competitive binding to the IL-23 receptors. Furthermore, a mixed population of murine colon carcinoma Colon 26 cells… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Similar Papers

Loading similar papers…