The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

Abstract

It is well established that the proteolytic processing of the beta-amyloid precursor protein (APP) generates beta-amyloid (Abeta), which plays a central role in the pathogenesis of Alzheimer's disease (AD). In contrast, the physiological role of APP and of its numerous proteolytic fragments and the question of whether a loss of these functions contributes… (More)

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@article{Ring2007TheSB, title={The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.}, author={Sabine Ring and Sascha W. Weyer and Susanne Kilian and Elaine Waldron and Claus U. Pietrzik and Mikhail A Filippov and Jochen Herms and Christian Buchholz and Christopher B. Eckman and Martin Korte and David P Wolfer and Ulrike Mueller}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2007}, volume={27 29}, pages={7817-26} }