The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice.

@article{Chen2013TheSK,
  title={The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice.},
  author={T Chen and Makoto Kuro-O and Cheng-hsien Chen and Yuh-Mou Sue and Yen-Cheng Chen and Ho-Han Wu and Chung-Yi Cheng},
  journal={European journal of pharmacology},
  year={2013},
  volume={698 1-3},
  pages={67-73}
}
Klotho was identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes. Nonetheless, the related mechanisms were still unknown. Many studies report that dietary phosphate restriction and genetic ablation of vitamin D pathways indirectly reverse premature aging processes in these mice. Furthermore, transgenic overexpression of klotho in mice extends their life span through inhibition of insulin and IGF1 signaling. We found… CONTINUE READING

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