The second messenger, cyclic AMP, is not sufficient for myelin gene induction in the peripheral nervous system.

@article{Poduslo1995TheSM,
  title={The second messenger, cyclic AMP, is not sufficient for myelin gene induction in the peripheral nervous system.},
  author={J. F. Poduslo and Randall Walikonis and M C Domec and C. T. van den Berg and C J Holtz-Heppelmann},
  journal={Journal of neurochemistry},
  year={1995},
  volume={65 1},
  pages={149-59}
}
The adenylyl cyclase-cyclic AMP (cAMP) second messenger pathway has been proposed to regulate myelin gene expression; however, a clear correlation between endogenous cAMP levels and myelin-specific mRNA levels has never been demonstrated during the induction or maintenance of differentiation by the myelinating Schwann cell. Endogenous cAMP levels decreased to 8-10% of normal nerve by 3 days after crush or permanent transection injury of adult rat sciatic nerve. Whereas levels remained low after… CONTINUE READING
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